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COXIBs, a new category of drugs that exert selective inhibition of COX-2, have been widely used for patients who have a high risk of cardiovascular and cerebrovascular diseases. Endothelial dysfunction (ED), as a marker of vascular injury, is involved in the initiation and progression of many cardiovascular diseases. ED also plays an important role in the pathogenesis of vascular remodelling, a leading factor for many cardiovascular and cerebrovascular diseases. However, the research on the effect of COXIBs on ED and vascular remodelling has been controversial. In this study, male Sprague Dawley rats were treated with two selective COXIBs, rofecoxib (0.05, 0.1 and 0.5mg/kg) and parecoxib (1, 10 and 100mg/kg) for 8 weeks. We found that COXIBs at low concentration (0.05 mg/kg) had no significant effect on femoral artery, and at high concentration (0.5mg/kg) induced significant endothelial dysfunction in rats. Otherwise, COXIBs at concentrations that did not cause the effect significantly reduced femoral artery after angiopoietin-like 4 (Angptl4) inhibition, i.e., in Angptl4 knockout rats. Furthermore, we found that the vasoactive substance, Angptl4, was expressed not only in the endothelium, but also in vascular smooth muscle cells (VSMCs) and fibroblasts. These results suggest that selective COXIBs do not necessarily exert their vascular injury effects through a direct mechanism, but may exert their injury effects via Angptl4-mediated pathways.//
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//
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