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In a live session at Barclays’ European Technology Alumni Club in London, he .Because the excitatory amino acids are involved in a variety of neurological processes, they must be effectively blocked to prevent their toxic effects. The pharmacological properties of these compounds suggest that N-methyl-D-aspartate (NMDA) receptor-mediated responses may be blocked more potently and more specifically with novel agonists and antagonists than with the currently available agents. The goal of this study is to investigate the structure-activity relationships of a new class of NMDA receptor antagonists which combines structural similarity to D-2-amino-5-phosphonopentanoic acid (D-AP-5) and novel pharmacophoric features. Other lead compounds will be prepared to enhance the affinity and/or potency and to expand the specificity of these compounds. It is hypothesized that the nature of the receptor site(s) that interact with the newer class of antagonists will be distinct from that of the other classes of NMDA receptor antagonists. Receptor-site analysis will be accomplished by radioligand binding and voltammetry to whole cells and single cells, respectively, using selective NMDA antagonists as ligands. The results obtained will be correlated with a computer-generated pharmacophore model for novel NMDA antagonists.You are here:

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The International Criminal Tribunal for the former Yugoslavia (ICTY) – an international institution that has been established by the United Nations Security Council – this week sentenced former Yugoslav President and General-heir Slobodan Milosevic, for crimes against humanity, genocide, violations of the laws and customs of war and crimes against humanity.

Indrek Pelmer, former Prosecutor on the ICTY, recently came to Finland from the United States to discuss the case of Slobodan Milosevic, and what lessons Finland needs to learn from it.HIV type 1 community prevalence among FSWs and their clients in Kerala State, India.
The prevalence of HIV infection was analyzed among female sex workers (FSWs) and their clients (HCs) who participated in a serial, cross-sectional study in Nagercoil in the southern Indian state of Kerala between 2003 and 2004. The prevalence of HIV infection was 2.5% (95% CI: 1.1-4.6) among FSWs and 6.2% (95% CI: 3.6-9.4) among their clients. The odds
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