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One of the first steps in treating hepatitis C is preventing patients from transmitting the virus. Although the best way to do that is with the most effective therapy, that doesn’t always happen; even with a cure, hepatitis C is still deadly. So now, we need a way to detect infection. Most commercial laboratories use polymerase chain reaction to test for the virus, but the analysis typically takes a week and costs $175. The CDC estimates that in 2014, more than 3 million Americans were infected with hepatitis C, a disease that causes liver damage, liver failure, and cancer.

Reaching patients earlier and cheaper is a top priority for researchers, but developing a test that could work outside of a clinical lab isn’t easy. At a theoretical level, it is possible to make test-on-site with the right hardware, but that can be complicated, expensive, and generally too slow to meet the real-time needs of clinical care. So for researchers, the most practical approach is to look for new biomarkers for the disease. In addition to making the test simpler to perform, biomarkers can provide new ways to detect and treat hepatitis C at a clinical level, as well as help identify new populations who are at high risk of the disease.

A small team led by Jennifer Ray, an assistant professor of chemical engineering at the University of Delaware and of chemistry and biochemistry at Medstar Georgetown University Hospital, has shown that a new type of electrochemical sensor can fulfill all three roles. With the electrical readout, the test could be performed on site. And because the new technology is very specific, it can pinpoint the presence of a particular virus.

The sensors are made of a single piece of glass coated with gold or silver. When a solution containing the sample

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