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/docs/Drd/Documents/Pc/Dv97e910/Pc/Dv97e910/Pc/Dv97e910/Pc/Dv97e910/Pc/Dv97e910/Pc/Dv97e910/Pc/Dv97e910/
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All Content on this Site is Copyrighted, please do not publish without specific permission. For any other questions or concerns, Email [email protected]N-methyl-D-aspartate receptor blockade does not alter wakefulness in rats.
N-methyl-D-aspartate (NMDA) receptors are known to play an important role in the maintenance of sleep. We studied the effects of infusing the NMDA antagonist, N-[3-(3-furyl) phenyl]-4-fluoro-2-methyl-5-oxo-1,2-thiazolyl]-N-methyl-benzamide (Ro 25-6981), on electroencephalographic (EEG) activity during sleep and on the duration of waking in the home cage in rats. EEG traces were used to evaluate sleep parameters (duration, frequency distribution, spectral power) and the latency of REM sleep episodes. Ro 25-6981 (0.2, 0.4, 0.6 mg/kg, i.v.) had no effect on sleep architecture. The latency of waking following the administration of Ro 25-6981 (0.4, 0.6 mg/kg) was increased by 74% and 40% in the second and third trial, respectively (P0.05). The latency of waking was not changed after saline administration (first trial: 26.5 +/- 1.2 min; P>0.05). However, Ro 25-6981 (0.4 mg/kg) increased the wakefulness latency (36.2 +/- 2.8 min; P
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